Pfizer Says Late-stage Coronavirus Vaccine Study Shows Moderate Side Effects

AstraZeneca COVID-19 vaccine trial in US on hold until at least midweek-sources

It was reported that the clinical trial had been put on hold in the US, UK, Brazil and South Africa.

The late-stage clinical trial for AstraZeneca's COVID-19 vaccine will be suspended in the United States for at least several more days, Reuters reported Monday, citing a source familiar with the matter.

The initial agreement with SIIPL announced in early August was a licensing deal to develop and commercialize the vaccine candidate in low- and middle-income countries and India. However, at the start of September, respected British medical journal The Lancet published a study prepared by the developers of Sputnik V, showing it to be 100 percent effective, producing antibodies in all 76 participants of early-stage trials.

The company has enrolled more than 29,000 people in its 44,000-volunteer trial to test the experimental COVID-19 vaccine it is developing with German partner BioNTech.

The other two are Moderna and AstraZeneca, which announced Saturday it would resume its trial after temporarily pausing it for safety reasons.

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"The proposed expansion would allow the companies to further increase trial population diversity, and include adolescents as young as 16 years of age and people with chronic, stable HIV (human immunodeficiency viruses), Hepatitis C, or Hepatitis B infection, as well as provide additional safety and efficacy data", the companies said.

The SII has submitted a revised participant information sheet, revised informed consent form, and an additional safety monitoring plan for the evolved participants. SII assured that no serious adverse events were experienced by any of the participants until the date of the reporting.

Global vaccine makers are racing to develop an effective vaccine against the virus that has killed more than 925,000 people since it emerged in China late a year ago.

Registered before the full set of three trial phases, the process of the vaccine's creation has been criticized by many scientists overseas for its rapid pace of production and improper testing.

China is the world's largest producer and consumer of vaccines, and can supply more than 1 billion doses of a vaccine annually from 40 manufacturers across the country, according to the 2018-2022 China Human Vaccine Industry Report.

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