Three-quarters of adults with COVID-19 have heart damage after recovery

Loss of smell from Covid-19 does not appear to be permanent scientists say after discovering crucial cells in the nose are still intact

The symptom, called "anosmia" by doctors, is one of the earliest and most commonly reported indicators of the virus. Originally, the researchers assumed that the virus attacks olfactory sensory neurons in the nose, "and damage [s] or kill [s] these neurons, and that's how we lose our sense of smell", said Sandeep Robert Datta, lead author of the study and an associate professor of neurobiology at the Blavatnik Institute at Harvard Medical School.

The study findings certainly require more research, said Dr. Amesh Adalja, principal investigator for the Johns Hopkins University Center for Health Safety, who was not involved in the new study.

In an effort to better understand why this particular symptom is so common among COVID-19 patients, an worldwide team of researchers led by neuroscientists at Harvard Medical School (HMS) was able to identify the olfactory cell types in the upper nasal cavity most vulnerable to infection by SARS-CoV-2, the virus that causes COVID-19.

The new study included analysis of blood samples from 18 Covid-19 patients, ages 21 to 81, and healthy donors, ages 20 to 64, based in Germany.

Their examination was distributed Friday in the friend evaluated diary "Science Advances". However, for some time, it was unclear why many Covid-19 patients lost their sense of smell. This study found greater amounts of viral nucleic acid - the genetic codes for proteins to produce new viruses - in children younger than 5 years. ACE2 are the receptors (or doors) that allow the virus to enter the body's cells.

India refutes China claims that disengagement along LAC now completed
He further said that both sides should properly handle differences to bring bilateral relations back to normal track. He said China was committed to peaceful development and did not present a "strategic threat" to India.

One of COVID-19's many mysteries may finally be solved. Datta explained that such damage would have the potential to permanently alter a person's sense of smell. I think the big question is trying to skip from the fact that they have these T cells to understand what the role of those T cells might be, "Adalja said".

That implies the infection is probably not going to make lasting harm olfactory neural circuits, which means patients can recoup their feeling of smell, the researchers said. This 2016 study, for example, found that in people with anosmia, symptoms of depression worsened with the severity of olfactory dysfunction.

"Anosmia seems like a curious phenomenon, but it can be devastating for the small fraction of people in whom it's persistent", Datta said.

More serious conditions of Anosmia that affect the brain or nerves, such as brain tumors or head trauma, can cause permanent loss of smell.

But, he added, "we need more data and a better understanding of the underlying mechanisms to confirm this conclusion". To show their new model's utility for testing vaccine candidates, the researchers immunized female mice with two doses of a recombinant subunit vaccine candidate and then infected them with the adapted virus.

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