Anti-cholesterol drug Praluent cuts death risk

As Praluent cuts death risks by 15%, Sanofi, Regeneron plot new push to win over payers

A first outcomes trial past year, called Fourier, similarly reported that Repatha, a different PCSK9 inhibitor called evolocumab, reduced the risk of death, heart attack, stroke, hospitalization for angina or revascularization procedures.

Regeneron Pharmaceuticals and partner Sanofi report new data this morning from a large, highly-anticipated trial suggesting that their drug alirocumab (Praluent) may reduce the risk of death for people with high cholesterol who have recently suffered heart attacks or strokes and are at risk of having another one or dying. This is for the first time when a cholesterol drug works effectively to reduce the death rate since statins.

Sanofi and Regeneron have pledged to make Praluent more accessible to patients as data show that the drug significantly cut the risk of cardiovascular events in high-risk patients. The new drugs clearly help people at high risk and are not aimed at people at low risk, such as those who have high cholesterol but have never had a heart attack, he said.

Alongside the data the companies announced plans to boost the affordability and accessibility of Praluent for patients most in need, by offering a reduced net price to United States payers that agree to reduce "burdensome access barriers" for high-risk patients. That price would be tied to an independent review of Praluent's value based on the new risk reduction data from the multi-year study called Odyssey Outcomes.

It is aimed at patients with high bad cholesterol levels at risk of a fatal heart attack or stroke.

"I've been unconvinced" of the drugs' benefits but now may prescribe them for certain very high-risk patients, said Duke University cardiologist Dr Christopher Granger.

Oil prices rise towards $70 fueling more subsidy fears
US crude CLcv1 fell 1.66 percent to $61.01 per barrel and Brent LCOcv1 was last at $64.58, down 1.39 percent on the day. In other trading, April gasoline fell 0.5% to $1.894 a gallon, while April heating oil fell 1.2% to $1.865 a gallon.

Results from the trial were presented during a late-breaker session at the American College of Cardiology's (ACC) 67 Annual Scientific Session in Orlando on Saturday.

Alirocumab inhibits the binding of proprotein convertase subtilisin/kexin type 9 (PCSK9) to the LDL receptor and thus heightens the number of available LDL receptors on the surface of liver cells. The trial was created to maintain patients' LDL-C levels between 25-50 mg/dL, using two different doses of Praluent (75 mg and 150 mg). If the drugs were used more broadly to treat all patients included in the trial, the cost-effective price would be in a range of $2,300 to $3,400 annually, ICER said.

"Sanofi and Regeneron have launched a new initiative that will expand access to their drug Praluent in the United States".

Dr Olivier Brandicourt, chief executive officer of Sanofi, said: "Too many patients in urgent need of additional treatment options on top of statins have faced tremendous hurdles to gain access to this important medicine". Insurers often balk at their high list prices, some $14,000 apiece per patient, per year.

The drug, Praluent, also led to fewer deaths among high-risk patients, which could be the strongest argument for insurers to finally remove barriers that have severely constrained sales and frustrated physicians trying to get the medicine to patients.

Related News:

  • Declassified Military Video Shows Fast-Moving UFO Tracked By Navy Fighter Pilots

    Declassified Military Video Shows Fast-Moving UFO Tracked By Navy Fighter Pilots

    He said they followed the "proper process" to get the video and that "the Department of Defense approved the release ". The video was released online by To the Stars Academy of Arts and Sciences , a private scientific research company.
    Kim's 'special message' for Trump sets media abuzz

    Kim's 'special message' for Trump sets media abuzz

    Luehrmann, Wright State University political science professor and director of the program in worldwide and comparative politics. He struggled for years to adjust to his new capitalist home before finding the sport he says now means "everything in life".
    Trump blocks Broadcom's takeover bid for Qualcomm

    Trump blocks Broadcom's takeover bid for Qualcomm

    Trump's decision to block Broadcom's pursuit of Qualcomm initially sent shares of the acquirer lower, but then they rebounded. US President Gerald R Ford signed an executive order creating Cfius in 1975, mainly as a vehicle to study foreign investment.
  • Mark Hamill to be 'guest of honour' for St Patrick's Day parade

    Mark Hamill to be 'guest of honour' for St Patrick's Day parade

    In addition to Mark's Star Wars connection, research into his family history has found that he has a double-link to Ireland. The second wave of Funko Pop! bobbleheads for Star Wars: The Last Jedi are arriving sometime this year.
    MS Dhoni backs Mohammed Shami over wife Hasin Jahan's allegation

    MS Dhoni backs Mohammed Shami over wife Hasin Jahan's allegation

    According to Jahan, the pacer had travelled to Dubai after India's tour to South Africa to meet a Pakistani girl. Instead of adding to the controversy, MSD said, "As far as I know, Shami is a great human being".
    Klopp asked whether Liverpool pair can win Ballon d'Or

    Klopp asked whether Liverpool pair can win Ballon d'Or

    Salah has been named player of the month for February and Klopp is delighted with his summer signing from Roma. They said we defended bad? If United get the first goal then they won't come out and give him that space.
  • Bills a 'team to watch' regarding Vikings QB Sam Bradford

    Bills a 'team to watch' regarding Vikings QB Sam Bradford

    The Denver Broncos have apparently worked out their quarterback situation ahead of the official start of free agency. What's the risk: That Keenum doesn't hold the form he showed last season , his sixth year in the NFL .
    Hillary Clinton: United States

    Hillary Clinton: United States "doesn't deserve Trump"

    Whether you see it that way or not, she does seem to suggest Trump subsisted on voters who were simply, well, less sophisticated or advanced.

    WWE Fastlane 2018: Results, Matches, and More

    The tag match between The Usos and The New Day was also uneventful mainly because The Bludgeon Brothers came in to interfere. John Cena had gone for broke in the match, Attitude Adjusting everyone in the beginning and leaving just him and Styles.
  • Budget session of Parliament: Stalemate on Day 6, protests continue

    Budget session of Parliament: Stalemate on Day 6, protests continue

    The only Congress member protesting in the Well was K V P Ramachandra Rao from Andhra Pradesh. I am allowing every issue to be raised and find no reason to disturb the proceedings.
    Huskers to Meet Mississippi State Wednesday in NIT First Round

    Huskers to Meet Mississippi State Wednesday in NIT First Round

    The Huskers will travel to Mississippi State to take on the fourth-seeded Bulldogs (22-11, 9-9 SEC). The Cornhuskers went 4-4 in their last eight games , but went 8-1 in the nine games before that.
    Bound flight makes emergency landing in Albuquerque after cabin fills with smoke

    Bound flight makes emergency landing in Albuquerque after cabin fills with smoke

    The airport tweeted their praise of the firefighters "for a quick response". "Just made an emergency landing in Albuquerque". A Dallas Police officer aboard the flight tweeted that Dallas-based Southwest's flight attendants "did a great job!"

Most liked

Dodgeville singer makes her mark on American Idol
I thought I was going to be the authority... but, no, no, I am the Kindergarten teacher. Noah Davis brought his love of alpacas and his wig-based lexicon to his audition.

S.Korean envoy briefs Japan officials
This is why the world looks forward to the meeting between US President Trump and North Korea's Kim Jong Un this coming May. Tillerson spoke Monday at a news conference in Nigeria. "We know the maximum pressure campaign is working", Sanders said.

Salma Hayek And Frida Kahlo's Family Object Barbie Doll
And the contract never granted the Corporation rights to Kahlo's image in the first place, only "certain uses of her name", he said.

South stars pay condolences to Sridevi's family at Chennai prayer meet
The actress had flown to the United Arab Emirates city to attend a family wedding and extended her star after the celebrations. She was known for her ability to slip into myriad roles, her expressive eyes, sheer comic timing and her fluid dancing skills.

Independent sex abuse inquiry will not fully investigate Telford scandal, MP fears
Out of 12 - mostly unconnected - victims who spoke to investigators from the Mirror , more than 70 abusers were accused. Mrs Jackson, 72, added: 'Lucy would climb out of windows in order to get out if she was grounded.

Southampton should replace Pellegrino with Mark Hughes - Robbie Savage
Mark Hughes has been named as the "leading candidate" for the vacant Southampton manager's position, not Marco Silva . Southampton legend Matt Le Tissier believes Mauricio Pellegrino was sacked because of his negative style of football.

[PyeongChang 2018] Amid passionate support, Winter Paralympic Games kick off
Mollie Jepsen, from Vancouver, won Canada's first medal, a bronze in the women's standing downhill and Mac Marcoux of Sault Ste. The 17 goals are tied for the second-most scored by Canada since Hockey Canada took over the sledge hockey program in 2004.

Arizona bride driving to wedding arrested for DUI
She was taken into custody and was taken to a sub-station where she had her blood drawn to determine her blood alcohol content. Scott added that a person in one of the other vehicles was treated at a local hospital for minor injuries.

Dramatic Video Shows People Try to Stop Driver From Fleeing After Crash
He then starts bashing in the windows of the auto , starting at the driver's side and working his way around the entire vehicle. In the video, the driver of a badly hit silver Infiniti SUV reversed the auto out of the scene of the wreck, trying to leave.

Singer Aditya Narayan Detained By Versova Police In Road Accident Case
In October past year , Narayan landed in trouble after he misbehaved with a staff member of the budget passenger carrier, IndiGo. Aditya has been granted bail on the guarantee of Rs 10, 000, and he has been asked to remain in the police station for the day.

96-year-old German "accountant of Auschwitz" dies before imprisonment
The district court of Lueneburg, in 2015, sentenced Groening to four years' imprisonment for aiding murder during the Holocaust. He was not involved in the actual killings, but counted cash taken from victims on their arrival at the camp.

Five dead in NY river helicopter crash
Luggage is not typically allowed inside "flightseeing" helicopters, according to Liberty Helicopters , which operated the flight. In July 2007 one of its helicopters went down in the Hudson with a pilot and seven passengers aboard, all of whom were rescued.

Judge rules $560M Powerball jackpot victor can remain anonymous
The judge dismissed the state's argument that disclosing her name would show the public that the lottery system is above board. The commission says it will consult with the attorney general's office to determine what to do next regarding the case.

Djokovic suffers 'weird' loss at Indian Wells as he returns from surgery
Grigor Dimitrov will not be in round three after the third seed fell to Spanish veteran Fernando Verdasco 7-6 (7/4) 4-6 6-3. He will now play against another American, Jack Sock, who beat Italy's Thomas Fabbiano 6-2, 7-5.

Virushka's rent for new flat is Rs 15 lakh per month
He captioned it, "Where else would you wanna be when you have such a stunning view from home!" She is seen kissing Indian captain and we can feel the lovely romance between them.